Chronic lung allograft dysfunction, the major cause of death following lung transplantation,
usually manifests as irreversible airflow obstruction associated with obliterative bronchiolitis
(OB), a lesion characterized by chronic inflammation, lymphoid neogenesis,
fibroproliferation and small airway obliteration. Spleen tyrosine kinase (Syk), a tyrosine
kinase that regulates B cell function and innate immunity, has been implicated in the
pathogenesis of chronic inflammation and tissue repair. This study evaluated the role of Syk …