Interleukin-17 receptor polymorphism predisposes to primary graft dysfunction after lung transplantation
J Somers, D Ruttens, SE Verleden… - The Journal of Heart and …, 2015 - Elsevier
Background Primary graft dysfunction (PGD), with an incidence of 11% to 57%, is a major
cause of morbidity and mortality within the first 30 days after lung transplantation (LTx). In
this study, we postulate that recipient genetic variants in interleukin-17 and-23 receptor
genes (IL-17R and IL-23R, respectively) may predispose LTx recipients to an increased risk
for developing PGD. Methods Seven genetic variants of IL-17R and IL-23R were
successfully genotyped in 431 lung transplant recipients. Our primary end-point was PGD …
cause of morbidity and mortality within the first 30 days after lung transplantation (LTx). In
this study, we postulate that recipient genetic variants in interleukin-17 and-23 receptor
genes (IL-17R and IL-23R, respectively) may predispose LTx recipients to an increased risk
for developing PGD. Methods Seven genetic variants of IL-17R and IL-23R were
successfully genotyped in 431 lung transplant recipients. Our primary end-point was PGD …
